Lynch Syndrome ICD-10-CM Codes

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What ICD-10 codes are used Lynch syndrome?Which Lynch syndrome ICD codes are billable?Clinical information Synonyms include Reference FAQS

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What ICD-10 codes are used Lynch syndrome?

Lynch syndrome, often referred to as hereditary nonpolyposis colorectal cancer (HNPCC), is a hereditary disorder that predisposes individuals to a higher risk of developing specific cancers, predominantly colorectal cancer.

Recognizing and accurately coding for Lynch syndrome is pivotal for appropriate patient care, risk assessment, and potential interventions. Below are the ICD-10 codes frequently associated with Lynch syndrome:

Z15.09: Genetic susceptibility to other malignant neoplasm: This code captures patients with a genetically increased risk for certain cancers, encompassing those associated with Lynch syndrome.
Z84.81: Family history of carrier of genetic disease: This code is designated for patients who have family members with known genetic disorders, inclusive of Lynch syndrome.
Z80.0: Family history of malignant neoplasm of digestive disorders: This code signifies a familial history of digestive system disorders, which can encompass cancers linked to Lynch syndrome.
Z80.8: Family history of malignant neoplasm of other organs or systems: This code applies to patients with a family history of malignancies in various organs or systems, including those that Lynch syndrome might impact, like the brain system or digestive organs.

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Which Lynch syndrome ICD codes are billable?

Z15.09: Yes
Z84.81: Yes
Z80.0: Yes
Z80.8: Yes

Clinical information

Lynch syndrome is an inherited genetic disorder passed down through generations and is the most common cause of hereditary colon cancer.
According to the National Cancer Institute (2025), individuals with Lynch syndrome face a heightened risk of developing colorectal cancer, as well as other cancers and malignancies, such as ovarian, stomach, and endometrial cancer.
Diagnosing Lynch syndrome early allows for proactive measures, potentially reducing the risk of cancer development.
Given its hereditary nature, families with a known history of Lynch syndrome are strongly advised to contact a genetic counselor to undergo genetic counseling and genetic testing. This provides clarity on potential risks and aids in informed decision-making.
Aside from collecting the patient's family and personal history, periodic screenings, such as colonoscopies, are crucial for Lynch syndrome patients. These screenings can identify precancerous changes or early-stage cancers, enabling timely intervention and increasing the chances of successful treatment.
Lifestyle modifications and certain medications might also be recommended to manage the risks associated with Lynch syndrome, in addition to screenings.