Macrocytosis ICD-10-CM Codes

Macrocytosis ICD-10-CM Codes

Learn about the ICD-10-CM codes associated with macrocytosis through this guide.

By Matt Olivares on Aug 8, 2025.

Fact Checked by Karina Jimenea.

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What ICD-10 codes are used for macrocytosis?

Macrocytosis refers to the presence of larger-than-normal red blood cells, often seen in blood tests. While it can indicate a variety of medical conditions, its accurate coding is vital for patient care, research, and medical billing. The ICD-10-CM offers standardized codes for this hematological finding.

There are no ICD-10 codes that have macrocytosis in their name, but that doesn't mean there aren't any. Only one ICD-10-CM code can be used for macrocytosis, and it's D75.89 - Other specified diseases of blood and blood-forming organs.

(Note: Macrocytosis, as a descriptive term for larger red blood cells, is often a laboratory finding and might not always have a direct ICD-10-CM code. You, the healthcare provider, would code for the underlying condition causing the macrocytosis.)

Is this lone macrocytosis ICD-10-CM code billable?

Yes. This lone ICD-10 code is valid and billable.

Clinical information

  • Macrocytosis denotes the presence of enlarged red blood cells (RBCs) often detected during a complete blood count (CBC) test.
  • Potential causes include vitamin B12 or folic acid deficiency, alcohol consumption, certain medications, liver disease, and bone marrow disorders.
  • Macrocytosis can be a sign of megaloblastic anemia, where the bone marrow produces fewer, but larger RBCs.
  • Treatment and management depend on identifying and addressing the underlying cause of macrocytosis.

Synonyms include

  • Megalocytic anemia
  • Macrocytic anemia
  • Presence of large red blood cells due to iron deficiency anemia
  • Presence of large red blood cells due to sickle cell anemia
  • Presence of large red blood cells due to folate deficiency anemia
  • Large red blood cells due to disorders involving blood-forming organs
  • Large red blood cell disorder
  • Presence of large red blood cells due to aplastic anemia
  • Presence of large red blood cells due to dietary folate deficiency
  • Presence of large red blood cells due to vitamin B12 deficiency
  • Enlarged erythrocytes
  • RBC macrocytosis

Popular search terms for macrocytosis ICD 10 codes

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Commonly asked questions

A macrocytosis ICD code should be used when a patient's blood test reveals the presence of abnormally large red blood cells and when there is a related medical diagnosis.

Treatment usually targets the underlying cause. This could range from vitamin supplementation (in the case of deficiency) to medication adjustments or addressing liver disease or alcohol consumption.

A diagnosis code for macrocytosis signifies the presence of larger-than-normal red blood cells in a patient, which can indicate various underlying conditions.

Related ICDs

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