F06.30 – Mood disorder due to known physiological condition, unspecified
Learn more about F06.30: Mood disorder due to known physiological condition, unspecified, its synonyms, related codes, billability, and more.

F06.30 diagnosis code: Mood disorder due to known physiological condition, unspecified
F06.30 is a diagnostic code in the ICD-10-CM system used for mood disorder due to a known physiological condition, unspecified. This diagnosis applies when a patient exhibits mood disturbances that are directly caused by a medical condition but lacks specification regarding whether the mood presentation is depressive, manic, or mixed.
Is F06.30 billable?
Yes, it is billable, meaning one can use it for insurance reimbursement.
Clinical information
- Mood disorders, including bipolar disorder current episode, major depressive disorder, and unspecified mood affective disorder, have no singular cause. However, several contributing factors may influence their development, such as neurochemical imbalances, genetic predisposition, environmental stressors, underlying medical conditions, distressing life experiences, and medication side effects.
- Patients with persistent mood disturbances may experience a range of emotional, behavioral, and physical symptoms that significantly impact their daily functioning. These symptoms can vary in severity and presentation, often aligning with conditions such as major depressive disorder recurrent, major depressive disorder single episode, or disorder affective psychosis NOS.
- One of the most common signs is changes in appetite and weight, which may involve significant weight gain or loss without intentional dietary changes. Patients may also exhibit altered sleep patterns, experiencing either insomnia or hypersomnia, which can further contribute to fatigue and decreased energy levels.
- Emotionally, individuals often struggle with feelings of excessive guilt, low self-worth, or inadequacy, leading to loss of interest in previously enjoyable activities. Persistent sadness, anxiety, or hopelessness may dominate their mood, making it difficult to engage in daily life.
- Behavioral symptoms can include irritability, hostility, or aggressive behavior, which may strain interpersonal relationships. In some cases, psychotic symptoms such as delusions or hallucinations may be present, further complicating the condition. Additionally, many individuals report physical discomfort, including recurrent headaches and stomachaches, which lack an identifiable medical cause but are linked to the underlying mood disorder.
- Healthcare providers typically conduct a comprehensive evaluation to determine the presence and severity of a mood disorder. This process begins with a medical history review, where clinicians assess preexisting conditions, risk factors, and any family history of mood or psychiatric disorders. Understanding a patient’s background helps identify potential triggers or contributing physiological conditions.
- A physical examination is also performed to rule out medical causes, such as neurological, endocrine, or metabolic disorders that could contribute to mood disturbances. In addition, healthcare providers use standardized screening tools to evaluate symptoms, their severity, and their impact on daily functioning.
- In cases where mood disturbances or manic episodes fluctuate, patients may exhibit symptoms consistent with major depressive disorder single, current episode mixed, or current episode manic. If panic disorder symptoms are also present, a more in-depth psychiatric evaluation is necessary to distinguish the condition from a primary anxiety disorder.
- Management of mood disorders varies based on symptom severity, underlying causes, and individual patient needs. Psychotherapy, including cognitive behavioral therapy (CBT), is a common first-line treatment to help individuals develop coping mechanisms and restructure negative thought patterns.
- Addressing the physiological cause is essential in treatment planning. This may involve managing underlying neurological, endocrine, or systemic conditions that contribute to mood disturbances.
- For severe and recurrent severe cases, particularly those with psychotic symptoms, a combination of pharmacological and therapeutic interventions may be necessary for symptom stabilization. Long-term treatment strategies often include continuous monitoring and adjustments to prevent relapse and improve overall mental health outcomes.
Synonyms include:
- Organic mood disorder
- Organic bipolar disorder
- Mood disorder due to a general medical condition
Other ICD-10 codes commonly used for mood disorders
- F06.0: Psychotic disorder with hallucinations due to known physiological condition
- F06.1: Catatonic disorder due to known physiological condition
- F06.2: Psychotic disorder with delusions due to known physiological condition
- F06.4: Anxiety disorder due to known physiological condition
- F06.8: Other specified mental disorders due to known physiological condition
- F06.31: Mood disorder due to a known physiological condition with depressive features
Commonly asked questions
A mood disorder due to a known physiological condition occurs when a medical illness, injury, or physiological factor directly causes significant mood disturbances. These mood changes can include depression, mania, or mood swings and are not attributable to primary psychiatric disorders or substance use. Proper diagnosis requires identifying the underlying medical condition responsible for the symptoms.
A major affective disorder refers to a category of psychiatric conditions that significantly impact mood, including major depressive disorder, bipolar disorder, and schizoaffective disorder. These disorders are characterized by persistent and severe emotional disturbances, such as prolonged depression or episodes of mania, that interfere with daily life. Treatment typically involves medication, psychotherapy, or a combination of both.
F06.31 is the ICD-10-CM code for mood disorder due to a known physiological condition with depressive features. As a primary diagnosis, it indicates that a patient’s depressive symptoms—such as low mood, fatigue, or loss of interest—are directly caused by an underlying medical condition rather than a primary psychiatric disorder. Management focuses on treating both the mood symptoms and the underlying physiological cause.