Autoimmune Disease ICD-10-CM Codes

What ICD-10 codes are used for autoimmune diseases

Autoimmune diseases are conditions in which the immune system mistakenly attacks the body's tissues. There are numerous autoimmune diseases, each with its specific code. Here are the commonly used ICD-10-CM codes for various autoimmune diseases, along with brief clinical descriptions:

• M05.9: Rheumatoid arthritis with unspecified rheumatoid factor: Used for rheumatoid arthritis when the specific rheumatoid factor status is unspecified.
• L93.0: Discoid lupus erythematosus: Applied for discoid lupus erythematosus, which primarily affects the skin.
• M32.9: Systemic lupus erythematosus, unspecified: Utilized when systemic lupus erythematosus is diagnosed, but the specific subtype is unspecified.
• M35.9: Systemic involvement of connective tissue, unspecified: Used for systemic involvement of connective tissue when the specific disease is unspecified.
• G35: Multiple sclerosis: Applied for multiple sclerosis, a chronic disease that affects the central nervous system.
• M32.10: Systemic lupus erythematosus, organ or system involvement unspecified: Utilized for organ involvement in systemic lupus erythematosus.
• L81.9: Disorder of pigmentation, unspecified: L81.9 refers to an unspecified disorder of skin pigmentation, meaning there is an abnormal change in skin color, but the exact type or cause hasn't been identified.
• M06.9: Rheumatoid arthritis, unspecified: Applied for rheumatoid arthritis when the specific subtype is unspecified.
• M34.9: Systemic sclerosis, unspecified: Utilized for systemic sclerosis (scleroderma) when the specific subtype is unspecified.
• M05.79: Rheumatoid arthritis with rheumatoid factor of multiple sites without organ or systems involvement: Used for rheumatoid arthritis with a positive rheumatoid factor affecting various joints, but without involvement of other organs or body systems.

Which autoimmune disease ICD codes are billable

The billable status of the mentioned ICD-10 codes for autoimmune diseases varies:

• M05.9: Rheumatoid arthritis with unspecified rheumatoid factor: Yes.
• L93.0: Discoid lupus erythematosus: Yes
• M32.9: Systemic lupus erythematosus, unspecified: Yes
• M35.9: Systemic involvement of connective tissue, unspecified: Yes
• G35: Multiple sclerosis: Yes
• M32.10: Systemic lupus erythematosus, organ or system involvement unspecified: Yes
• L81.9: Disorder of pigmentation, unspecified: Yes
• M06.9: Rheumatoid arthritis, unspecified: Yes
• M34.9: Systemic sclerosis, unspecified: Yes
• M05.79: Rheumatoid arthritis with rheumatoid factor of multiple sites without organ or systems involvement: Yes

Clinical information

• Autoimmune diseases refer to disorders involving the immune system in which the body mistakenly targets and attacks its own tissues and organs. These conditions may also be considered functional disorders of immune regulation, where the immune mechanism fails to distinguish self from non-self.
• There are over 80 known autoimmune diseases, each affecting different tissues or organ systems—ranging from rheumatoid arthritis (joints) to multiple sclerosis (nervous system). Many of these conditions share similarities with certain disorders in complement system immunodeficiency disorders, where immune regulation is impaired.
• Diagnosis requires a comprehensive medical history, physical examination, and specialized laboratory testing to detect autoantibodies or abnormalities in immune markers. In some cases, these may overlap with markers found in syndrome immunodeficiency or severe combined immunodeficiency, especially when evaluating complex or early-onset cases.
• The causes of autoimmune diseases are often multifactorial, involving genetic predisposition, environmental exposure, and occasionally infections like human immunodeficiency virus, which may trigger or exacerbate disorders involving the immune system.
• Management is tailored to the specific condition and may include immunosuppressive therapy, corticosteroids, or disease-modifying treatments to reduce inflammation and slow progression.
• Patient education is key to improving outcomes, focusing on adherence to treatment, lifestyle adjustments, and early detection of flare-ups. In chronic or complex presentations, autoimmune diseases may be part of a classified disorder or associated with unspecified immune diseases.
• Long-term follow-up is essential for monitoring therapeutic response, managing side effects, and assessing quality of life. Multidisciplinary care involving rheumatologists, immunologists, and organ-specific specialists ensures effective oversight, especially in patients who may also be dealing with complications such as transplant failure, involvement of blood-forming organs, or overlap with many autoimmune diseases.
• Autoimmune conditions can significantly affect daily life, requiring psychological support and continuous care to manage both the physical and emotional impact.

Synonyms include

• Autoimmune disorders
• Autoimmune conditions
• Autoimmune illnesses
• Autoimmune syndromes
• Autoimmune system diseases